The prevalence of diabetic kidney disease (DKD) is increasing year by year. DKD is one of the most common microvascular complications of diabetes and has become the main cause of end‐stage renal failure. In recent years, the clinical application of many new hypoglycemic drugs has been increasing gradually, which can effectively reduce blood glucose while showing different degrees of renal protective effect. The renal outcomes of different novel hypoglycemic agents in the treatment of type 2 diabetes were compared and the effect of the use of these novel agents on DKD progression was discussed.