With the continuous development of information technology, geographic information system (GIS) has been widely used in many fields, which has promoted the continuous improvement of social production level. In local land management, it can improve the land utilization rate and give full play to the value of land. This paper introduces the general situation of GIS, and based on GIS technology combined with the actual situation of regional land use, expounds the application of GIS in regional land use decision-making, which is beneficial to the popularization and application of GIS, and has particularly important reference value for technicians engaged in related work.