Cold atmospheric plasma is an emerging field in medicine, especially in dermatology with promising applications for skin aesthetics, wound healing, skin malignancies, and the treatment of various skin diseases (e.g., psoriasis, atopic dermatitis, scleroderma, etc.). Among them, the most studied is the role of plasma in wound healing. This paper reviews three aspects of the mechanisms by which cold atmospheric plasma promotes wound healing, details the effects of cold atmospheric plasma on skin cells, skin tissues, and on trauma‐loaded microorganisms, and provides a brief analysis on the biosafety of cold atmospheric plasma.