In emergency situations, the prognosis for the patient's outcome is determined by how quickly fluid access is established and resuscitation with fluids and drugs is administered. Because peripheral veins collapse in critically ill patients with shock, limb defects, and severe burns, it is difficult for medical staff to quickly establish insertion of a peripheral venous catheter. In recent years, the application of intraosseous infusion in early adult fluid resuscitation has received a lot of attention and investigation. However, clinical data from current large‐scale clinical RCTs on intraosseous infusion and training of medical staff are insufficient. It is important that rapid and safe administration of IO infusion for parenteral access in patients with difficult venous access is possible. This article focuses mainly on a literature review of advances in the clinical application of IO.