- 期刊
Adult Neurogenesis: Does Knockout of NMDA Receptors in Newborn Neurons Reduce the Antidepressant Effects of Fluoxetine?
摘要
Patients with Major depressive disorder( MDD) all present different degrees of funcion deficit in their hippocampus. As the hippocampus primarily involves memory and learning function, the patients with MDD always experience decline in learning abilities. The glutamate in the hippocampus-NMDA receptor, has proved to involve learning and memory function in the hippocampus. Thus, we hypothesize that the presence of NMDA receptors can affect depression. On the basis of this, we propose that the knockout of NMDA receptors can reduce the effects of antidepressant drugs. And the NMDA receptors in newborn neurons play a more important role in controlling depression than those in old neurons.
參考文獻
Reddy, M. S. (2010, January). Depression: The disorder and the burden. https://www.ncbi. nlm. nih. gov/ pmc/articles/PMC3137804/
Sapolsky, R. M. (2001, October 23). Depression, antidepressants, and the shrinking hippocampus. https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC60045/
Tunc-Ozcan, E., Peng, C.-Y., Zhu, Y., Dunlop, S. R., Contractor, A., & Kessler, J. A. (2019, August 21). Activating newborn neurons suppresses depression and anxiety-like behaviors. Nature News. https:// www.nature.com/articles/s41467-019-11641-8.
Taupin, P. (2006, October 26). Neurogenesis and the effect of antidepressants. Drug target insights. https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC3155214/.
Rezvani, A. H. (1970, January 1). Involvement of the NMDA System in Learning and Memory. Animal Models of Cognitive Impairment. https://www.ncbi.nlm.nih.gov/books/NBK2532/.