- 期刊
An Overview of Depression and Two Antidepressants--Selegiline and Fluoxetine
摘要
In response to depression, several types of drugs have already been invented by scientists and drug companies, and two of most well-known drugs are monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRIs). Two drugs, selegiline and fluoxetine, are selected from these two categories, respectively, to be discussed here. This brief review will include an introduction of depression as a disease, two categories of antidepressants, selegiline (EMSAM^(TM)) and fluoxetine (Prozac^(TM))'s chemical structure, pharmacology, syntheses pathways, and pharmacoeconomic. In the pharmacology part, the receptors of the drugs, the inhibition mechanism, delivery of drugs, pharmacokinetics will be discussed. Finally, a comparison of side effects of these two drugs is discussed, and an overview of recent development in antidepressants is provided. This overview reviews selegiline and fluoxetine in the background of antidepressants development and stresses their serious side effects, and it points out the limitedness of research horizon of antidepressants, which mainly focused on monoamine neurotransmitters, in the 20^(th) century. These can encourage more antidepressants development in reducing side effects as well as promoting new mechanisms in the future.