- 期刊
Andrographolide Alleviates S. Pneumoniae Bacterial Meningitis as an NF-κB Pathway Inhibitor and Antibiotic
摘要
Meningitis is a severe inflammatory response in the central nervous system (CNS). Patients may suffer from irreversible damages to their brains. This research finds a new way to cure meningitis since the overactivation of the NFkB pathway results in severe meningitis inflammatory response. And andrographolide (andro) can inhibit the canonical NFkB pathway by blocking the phosphorylation and translocation of p65. Together with its antibiotic ability, andro is theoretically suitable for curing bacterial meningitis. No one has tried to use andrographolide to alleviate meningitis, this work designed experiments to test the ability of andrographolide.
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