In information theory, n-gram was defined as any n-long sub-sequences of consecutive tokens in a sequence. Since late 1940s, it has developed and applied in multiple fields of technology. This paper introduced the main three applications of n-grams in the prediction of English language model, genomes, and COVID-19 virus. In predicting English, entropy of n-gram was used to calculate the uncertainty on average of the next English letter when the previous N-1 English letters were known. It was also used to categorize and characterize genomes, etc. Under serious COVID-19 condition, n-gram precisely identified the origins of COVID-19 from different locations as well as presented the psychological effect of COVID-19 virus through social media. N-gram is a promising method for future use in multiple areas.