Beginner Guide to Retrosynthesis Analysis

Tengyue Ren

《International Core Journal of Engineering》 7卷7期 (2021/07) Pp. 159-164

https://doi.org/10.6919/ICJE.202107_7(7).0023

摘要

Retrosynthesis Analysis is an important technique in Organic Chemistry. There can be many ways a molecule can be form. It can be difficult for new organic student to construct an efficient pathway for a target molecule. In this work, four useful guiding principles were introduced and explained which can help student to determine crucial steps when deconstructing a target molecule. The general goal for these principles is to simplify the target structure as much as possible by using molecules shape and structure. The ＂common ion＂ approach is emphasized for its effectiveness, and accuracy. By breaking bonds between two common ions, the target molecule can be separated into two much simplified molecules. Other retrosynthesis principles focus on mainly using molecule's symmetry to simplify a target molecule.

關鍵字

Retrosynthesis Analysis Beginner Guide ； Common Ion Approach ； Simplify Complexity

參考文獻

Badami, B. V. (2019). Erratum to: Retrosynthetic Analysis. Resonance, 24(12), 1523–1523. https://doi. org/10.1007/s12045-019-0913-2, pp.1080.

Joel Karty. Organic Chemistry Principle and Mechanisms 2nd Edition. Chapter 13, pp.649- 650.

Rowlands,G.(n.d.). Retrosynthesis. Internetchemistry. https:// www. internetchemistry. com/ chemistry/ retrosynthesis. php#lectures.

Dr. Ram Singh, Dr. Geetu Gambhir, 14: Organic Chemistry –IV (Advance Organic Synthesis and Supramolecular Chemistry and carbocyclic rings), 4: Two group C-X disconnections. SGTB Khalsa College, University of Delhi, 3.1 1,2-Disconnection approach.

Clayden, J., Greeves, N., & Warren, S. G. (2013). Solutions manual to accompany organic chemistry. Oxford Univ. Press. Chapter 28, pp 291.