This paper analyzes the stability and oil displacement efficiency of the displacement control agent PF601 in different mineralization degree and temperature for 30 days, and the influence on the wettability of the core, and proves the economic feasibility of the flooding agent PF601. The results show that the temperature and salt resistance of the reservoir is good, the ultra-low interfacial tension is maintained in 30 days, the contact angle is obviously reduced, the permeability is smaller, the plugging effect is better, so as to improve the recovery rate of this kind of reservoir.