The generation, measurement, and applied technologies of so-called nano-bubbles or ultra-fine bubbles, with a diameter that ranges from tens to hundreds of nanometers, are evolving dramatically in recent years. Due to their unique properties, nano-bubbles are used in several applications such as manufacturing of functional materials, decontamination, pharmaceutical delivery, and disinfecting food products. In this study, a newly developed methodology for nano-bubble on mineral industrial intelligent manufacturing was proposed and designed. This has expanded our understanding towards the utilization of micro to nano bubbles. The findings will have potential benefits in developing efficient and sustainable processes for industries to minimize chemical usage and environmental damage.