According to the advantages of light weight, high strength and strong plasticity of materials, the lightweight design of automobile hub is carried out to reduce weight under the condition of meeting the use requirements. In this study, the wheel hub model is established by UG, and the software ANSYS WorkBench is imported for analysis. The finite element analysis method is used to analyze the bending fatigue, radial fatigue and impact simulation test of structural steel materials. The results show that the stress value under three working conditions is less than the yield strength of the material, and the deformation meets the requirements of normal working conditions. According to the results of finite element static analysis and modal analysis, the magnesium alloy and aluminum alloy materials were replaced for the structural steel wheel hub, and the strength was checked. The results show that the magnesium alloy wheel hub and aluminum alloy meet the design requirements and the weight is greatly reduced. The structure of the hub was optimized, and the size was optimized with the thickness of the rim, the thickness of the spoke and the thickness of the installation plate as the main design variables. The optimization results show that the thickness of the rim is reduced by 10 % compared with that before optimization, the thickness of the spoke is reduced by 29.6 % compared with that before optimization, and the thickness of the installation plate is reduced by 29.03 % compared with that before optimization. The strength of the optimized hub is checked. The results show that the stress and strain of the three hubs are increased after optimization, but still meet the design requirements. By comparing the three hubs, it is found that aluminum alloy hubs can better meet the lightweight requirements and cost requirements, and carbon fiber hubs have more lightweight requirements.