In recent years, the Chinese government has invited many internationally renowned architects to design some local landmark buildings, and Zaha is one of them. The article first introduces the basic situation and cutting-edge design concepts of the Guangzhou Opera House designed by Zaha. The second part will discuss Guangzhou's geographical and economic background and the architectural culture and style of the Pearl River Delta. The last part will examine whether the Guangzhou Opera House has ignored cultural identity and regionalism.