Expression and Significance of KLKB1 in Hepatocellular Carcinoma based on Multiple Gene Databases

Yuewen Qi ； Haowen Qi ； Bingqing Li

《International Core Journal of Engineering》 8卷4期 (2022/04) Pp. 210-216

https://doi.org/10.6919/ICJE.202204_8(4).0028

摘要

Background: The expression and mechanism of plasma kallikrein B1 (KLKB1) in hepatocellular carcinoma were analyzed by deeply mining the gene information in Oncomine and other databases. Methods: The BioGPS database was used to analyze the expression of the KLKB1 gene in normal tissues. Collect the information about the study of KLKB1 in Oncomine database and analyze its expression level in hepatocellular carcinoma. Kaplan Meier method was used to analyze the relationship between the expression level of KLKB1 and the survival of patients with liver cancer, and to explore its clinical significance. The proteins related to KLKB1 gene were collected by GeneCards database, and the network diagram of KLKB1 related proteins was drawn by string to analyze the physiological process of protein enrichment. Result: The relevant results of the BioGPS database analysis showed that KLKB1 is under-expressed in normal liver tissue. Three studies on the differential expression of KLKB1 gene between liver cancer and normal liver tissues were collected in Oncomine database. Data analysis showed that the expression of KLKB1 gene in liver cancer tissues was significantly lower than that in normal liver tissues (P ＜ 0.05). Kaplan Meier survival analysis showed that the overall survival time of liver cancer patients with low expression of KLKB1 gene was significantly shorter than that of patients with low expression, and the prognosis of patients with high expression was better (P＜ 0.05). GeneCards database collected 25 proteins related to KLKB1, including HGF, TFPI2 and C1QBP. The enrichment analysis results of related proteins showed that they were mainly enriched in physiological processes such as coagulation process, protein activation process, positive regulation of fibrinolysis. Conclusion: KLKB1 gene may play a role in the occurrence and development of liver cancer by regulating the process of hemagglutination. Low expression suggests that the prognosis of patients with liver cancer is poor. Targeting KLKB1 may be a potential tool for tumor diagnosis and treatment.

關鍵字

Hepatocellular Carcinoma ； KLKB1 ； Multiple Gene Databases

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