Printing and dyeing wastewater is recognized as one of the most difficult wastewaters at home and abroad because it contains dyes with stable chemical properties and difficult to be biodegraded. It has become one of the research hotspots to screen microorganisms that can efficiently decolorize and degrade dyes and apply them to the treatment of printing and dyeing wastewater. The decolorization and degradation of dyes by a single decolorizing bacteria has shortcomings such as low efficiency, incomplete degradation, and easy formation of secondary pollution. Mixed bacteria can not only overcome these shortcomings, but also have its own significant advantages, such as synergistic improvement of decolorization efficiency and environmental conditions. The development of mixed bacteria co-culture system is expected to solve the problem of refractory printing and dyeing wastewater.