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A Systematic Review of Diffusion Tensor Image Analysis along the Perivascular Space and its Clinical Applications

摘要


The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method is used to assess the glymphatic system function in subjects for non-invasive purpose. Growing research suggests an association between various diseases and glymphatic system dysfunction. This review focusses on the application of the DTI-ALPS method in various diseases. Furthermore, the relationship among ALPS index, cognitive function and glymphatic system activity is systematically summarized.

參考文獻


T. Taoka, Y. Masutani, H. Kawai, et al. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases, Japanese Journal of Radiology, vol. 35 (2017), 172-178.
T. Taoka,S. Naganawa. Glymphatic imaging using MRI, Journal of magnetic resonance imaging : JMRI, vol. 51 (2020), 11-24.
T. Taoka, R. Ito, R. Nakamichi, et al. Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study, Jpn J Radiol, vol. 40 (2022), 147-158.
J.J. Iliff, M. Wang, Y. Liao, et al. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β, Science Translational Medicine, vol. 4 (2012).
C. Tan, X. Wang, Y. Wang, et al. The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus, Clin Interv Aging, vol. 16 (2021), 139-153.

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