Since the concept of aggregation‐induced luminescence (AIE) was first proposed by Professor Tang Benzhong in 2001, it has been widely concerned by domestic and foreign colleagues. Aie provides a new way to solve the problem of aggregation‐induced fluorescence quenching. At present, AIE has developed into an international frontier field pioneered and led by Chinese scientists. Compared with traditional organic fluorescent dyes, AIE materials show some significant advantages in biological imaging applications, such as high aggregation luminescence efficiency, good photostability, strong photobleaching resistance, diverse structure, strong modifiability, adjustable absorption and emission, and good biological compatibility. However, AIE fluorescent dyes still face some challenges. For example, the luminescence of AIE materials is mostly concentrated in the UV‐visible region. This part of the spectrum coincides with the absorption band of hemoglobin in mammals. In order to avoid being absorbed by tissues in vivo and improve tissue penetration during imaging, AIE materials that are absorbed and emitted in the near infrared region need to be designed and synthesized.