This review examines the cutting-edge advancements in soft integrated sensor systems, underscoring their pivotal role in the evolution of next-generation electronics for applications spanning health monitoring, environmental sensing, human-machine interfaces, and the Internet of Things. The discussion centers on the development of stretchable sensors that exhibit heightened flexibility and sensitivity, the critical role of sensor arrays in facilitating multi-point measurements, and the ongoing challenges in their manufacturing. The integration of sensors with circuits is highlighted as essential for achieving multifunctional capabilities, with a focus on the progress of multimodal sensors that can detect an array of chemical and physical signals. The abstract concludes by emphasizing the imperative to further refine high-performance integrated sensor systems, addressing key challenges in stability sensing and wireless communication to realize their full potential in the realm of smart electronics.