To accurately measure the viscous and inertial resistance coefficients of micro/nanoporous membranes, an experimental platform was designed and constructed to characterize their resistance properties. The experiment involved measuring pressure drop variations at different flow velocities and fitting their relationship to precisely determine the viscous resistance coefficient. To ensure the reliability of the experimental data, computational fluid dynamics (CFD) simulations were performed to conduct a numerical analysis of the experimental results. A comparison between the simulation and experimental data confirmed the feasibility and effectiveness of the proposed measurement method. The findings of this study have broad applications in fields such as gas diffusion, electrodialysis, and filtration-separation, providing valuable insights for enhancing the practical performance of micro/nanoporous membranes.