Industrial transformation and upgrading has become the main theme of social and economic development, which has an important impact on the development of vocational education. Accelerating the supply-side reform of highly skilled personnel training is an inevitable choice to adapt to the development of regional strategic emerging industries. At present, the structural contradiction between the supply of highly skilled talents and industrial transformation and upgrading is obvious, which is reflected in the different degrees of deviation between the hierarchical structure of vocational education, professional settings, talent training standards, curriculum system schooling mode and industrial development demands. Therefore, it is necessary to connect with the development of strategic emerging industries, build a professional system connected with the industrial chain and job chain, optimize the regional layout, innovate the form structure of talent supply, and build a diversified school mode to meet the precise connection between strategic emerging industries and highly skilled personnel training.