Research shows that colorectal cancer has become one of the most common malignancies in the world. Its incidence rate ranks third in the world among all kinds of tumors, and its mortality rate ranks second in the world. In China, the incidence of colorectal cancer is also increasing year by year. In recent years, a large number of studies have shown that dihydroartemisinin, an antimalarial component of traditional Chinese medicine, has a certain anti‐colorectal cancer effect, which has attracted widespread attention. This paper summarizes and analyzes the effect of dihydroartemisinin in anti‐colorectal cancer and the possible mechanisms involved in recent years. Meanwhile, it provides a reference for the clinical application and pharmacological research of dihydroartemisinin.