The great spirit of fighting against the epidemic is the continuation and development of the socialist core values at the national, social and individual levels. The great spirit of fighting against the epidemic originates from the anti‐epidemic practice, and at the same time is higher than the anti‐epidemic practice. It has a strong practical significance to integrate the great spirit of fighting against the epidemic into the cultivation of the core socialist values of college students. There are four levels of public opinion and practice of the great spirit of fighting against the epidemic to realize the all‐round integration of the great spirit of fighting against the epidemic into the cultivation of the socialist core values of college students.