The interdisciplinary approach has been a trend for a comprehensive dental treatment. Within modern dentistry, periodontics and prosthodontics share an intimate and inseparable relationship in multiple aspects, including treatment plan, procedures execution, outcome achievement and maintenance. By controlling inflammation and preparing sites for proper prosthetic prostheses, periodontists no doubt can provide a solid foundation for successful prosthetic outcomes. On the other hand, prosthodontists could construct proper restorative margin, shapes and contacts that benefit the harmony of periodontium and prosthesis. This article was aimed at addressing the key relationship between prosthodontics and periodontics. The impacts of healthy periodontium on longevity of prostheses were addressed. In addition, how the restorative factors such as biologic width violation, retraction techniques and defective restorations, influenced on periodontal/ peri-implant tissues were also discussed. This systematic review also comprised the association between the presence of residual cement and the occurrences of peri-implant diseases. In short, frequent and efficient communications are essential between periodontists and prosthodontists through the entire treatment procedures to ensure an overall successful treatment since both specialties share a common goal: to create pleasing esthetic with a harmonious stomatognathic system.