Mucosa lesions related to denture frequently occur. Epulis fissuratum is a tumor-like fibrous hyperplasia that arises due to irritation of poorly adapted denture. It can appear as a single or multiple folds located over the vestibular sulcus around the overextended border of denture. It is important to eliminate the irritation as it can also lead to malignant lesion such as carcinoma if ignored for a long time. The treatments include surgical removal of the lesion and provision of appropriate prosthetic reconstruction. This article presents a case that applied conventional surgical excision to remove epulis fissuratum followed by a new denture fabrication to achieve acceptable function and esthetics for patient.