Patients with poor occlusal support suffer from unequal bone resorption, leading to an uneven occlusal plane. A telescope overdenture could be a promising treatment option for full mouth reconstruction to maintain healthy teeth and balance the unfavorable occlusal pair. Interest in fabricating digitally assisted removable dentures has focused on using intraoral and extraoral scanners, computer-aided design software, and computer-aided manufacturing machines since they may offer faster treatment, better prosthesis fit, and ease of denture duplication. This clinical report describes a method combining digital scanning devices and a 3D milling/printing process with conventional procedures to fabricate telescope dentures for a 66-year-old male patient. The intraoral scanner helped capture the detailed surface structure of the natural abutment teeth and edentulous ridge. Interim dentures could be scanned and converted into 3D data for superimposing digital models to duplicate intermaxillary relationships. Multiple materials were applied during treatment, including zirconia inner crowns, a selective laser melting manufactured titanium metal framework, 3D-milled polymethylmethacrylate artificial teeth, and conventional denture base resin. This digitally assisted method and packing procedure provided a more efficient and precise way to fabricate telescopic overdentures. During the 1.5-year follow-up period, the patient was satisfied with his dentures, masticatory function, and improved physical appearance.