The purpose of this study is to explore the impact of life adaptability of Chinese college students studying in Thailand on mental health problems, with cross-cultural adaptation as the moderating variable. The results of descriptive statistics, reliability and validity analysis, correlation analysis and regression analysis showed that, there are no significant difference in the dimensions of cross-cultural adaptation, college student' life adaptability and college students' mental health problems between the grade level and the duration of residence in Thailand; College students' life adaptability, family, interpersonal relationship, emotion and self-worth have significant positive effects on college students' mental health problems; Intercultural adaptation has no moderating effect on college students' life adaptability and mental health.