Economic vitality is an important index to measure the development of a city, so the factors that affect the vitality of the city have become the key to promote the development of the city. However, the impact of various factors on urban vitality is different and difficult to measure, which limits the targeted development of the city. If the influence of various factors on urban vitality can be accurately analyzed, a series of policies can be put forward to promote the development of urban vitality according to local conditions. This article takes Tianjin as an example to explore the problem of regional economic vitality affected by many factors.