With the improvement of people's quality of life, consumers improve the requirements of food safety. This makes the cold chain logistics known to the public, and greatly improves the development speed of the cold chain logistics industry. However, as an emerging industry, cold chain logistics still has many external or internal problems based on food safety, which hinder the development of cold chain logistics industry. In this case, the development of cold chain logistics is imminent, so the research of this paper solves this problem to a certain extent. Firstly, this paper points out the overview of cold chain logistics based on food safety; secondly, it describes the current situation of food safety in domestic cold chain logistics; secondly, on this basis, it finds and analyzes the domestic cold chain logistics problems about food safety; finally, it puts forward development strategies according to the problems, so as to provide reference for China' s cold chain logistics industry.