In the context of "The Belt and Road Initiative", cross-border e-commerce has gradually become an important pillar of international trade. As the capital city of Guangzhou, it has a unique advantage and an important role in promoting the development of cross-border e-commerce industry in Guangdong Province. This paper analyzes the characteristics of the demand for cross-border e-commerce talents in Guangzhou from the perspective of enterprises through a questionnaire survey, so as to summarize the relevant countermeasures for the cultivation of cross-border e-commerce talents in Guangzhou and promote the further development of cross-border e-commerce in Guangzhou.