Design a system based on electrically driven two-axis resonance fatigue loading. In order to eliminate the coupling effect of the two loading sources in the blade fatigue test, a cross-coupling structure based on a sliding mode variable structure control algorithm is proposed to design an error following controller. The Lyapunov function was used to verify the stability of the algorithm, and a two-axis resonance fatigue synchronization control test bed for wind turbine blades was built to verify the synchronization control effect of the algorithm. The experimental results show that the following effect of the two exciters is fast and the synchronization state can be better maintained. The inherent phase difference caused by the electromechanical coupling is basically eliminated. The speed error of the two loading sources is within 5%, which meets the requirements of biaxial resonance fatigue loading.