Regional economic integration has become one of the main trends and important characteristics of world economic development. With the continuous improvement of market mechanism, the coordination of macro-control by the central government and the initiative of local governments, typical regions in China have formed their own development models and embarked on the integration path suitable for their own development, the choice of the Yangtze River Delta region as the research object. With the new policy published, the Yangtze River Delta urban agglomeration needs to improve after meeting its own development bottleneck. The economic integration of various economic regions is also facing many difficulties and obstacles, the situation of Yangtze River Delta is one of the examples, which may reflect the overall development of China. Due to the complex region development, this paper focuses on the analysis of main economic indicators of the main cities in Yangtze River Delta, and discussion on the integrated development of the Yangtze River Delta and the main problems facing the region and puts forward the corresponding countermeasures.