The exchange rate of the national currency reflects the external value of the currency to some extent. With the advancement of RMB internationalization, RMB exchange rate plays an increasingly important role in Chinese and world economic activities.In the new era, the RMB exchange rate is affected by more new events such as the novel coronavirus epidemic and the US Federal Reserve's interest rate hike. This paper selects a total of 14 years' data from 2009 to 2022, takes RMB as the exchange rate as the research object, and constructs a multiple linear regression model to comprehensively analyze the influence of traditional common factors GPD, CPI, foreign exchange reserve scale and new factors such as the intensity of COVID‐19 in different periods and the Federal Reserve's interest rate hike on RMB exchange rate. And make relevant policy recommendation accordingly.