- 期刊
Could Antibiotic Prophylaxis in Cirrhotic Patients with Acute Variceal Bleeding Prevent Rebleeding?
摘要
Background: Acute variceal bleeding is associated with a high incidence of bacterial infections. Presence of bacterial infections in patients with acute variceal bleeding has been incriminated as an important predictive factor for treatment failure and variceal rebleeding. Meta-analysis showed that antibiotic prophylaxis in cirrhotic patients with gastrointestinal hemorrhage could effectively reduce bacterial infections with improved survival. Antibiotic prophylaxis has also been shown to reduce variceal rebleeding. Thus, antibiotic prophylaxis has been regarded by practice guidelines as an integral part of therapy for cirrhotic patients presenting with upper gastrointestinal bleeding. Actually, a lot of factors are involved in the occurrence of variceal rebleeding. Some studies did not reveal that antibiotic prophylaxis could reduce variceal rebleeding. This review tries to focus on the issue of whether antibiotic prophylaxis in cirrhotic patients with acute variceal rebleeding could truly reduce variceal rebleeding.