Tribulus Terrestris Induces the Relaxation of Porcine Coronary Artery

Shu-Leei Tey ； Ching-Chung Tsai ； Li-Wei Lin ； Yea-Ling Chen ； Li-Ching Chang ； Pei-Ling Wu ； San-Nan Yang

《E-Da Medical Journal》 8卷3期 (2021/09) Pp. 1-7

https://doi.org/10.6966/EDMJ.202109_8(3).0001

摘要

Objectives: Angina pectoris is usually due to spasm or obstruction of the coronary arteries that furnish blood to the heart muscle. Clinical symptoms include chest pain and discomfort, and the discomfort also can happen in patient's jaw, shoulders, arms, neck, or back. The medications in traditional Chinese medicine are a few for angina pectoris in clinical practice. Furthermore, the effect of Tribulus terrestris (T. terrestris) on coronary artery is unclear. Methods: T. terrestris and its active ingredients including kaempfrol, ruscogenin, protodioscin, protogracillin, and harmine were used in this study to examine their effect on porcine coronary artery. Results: The results showed T. terrestris can induce relaxation of porcine coronary artery in a dose dependent manner after U46619-induced contraction. Conclusions: The results provide a potential to develop T. terrestris for the treatment of angina pectoris in traditional Chinese medicine.

關鍵字

angina ； Tribulus terrestris ； coronary artery ； relaxation

參考文獻

Kloner RA, Chaitman B.: Angina and Its Management. J Cardiovasc Pharmacol Ther 2017;22(3):199‐209.

Zhuo Q, Yuan Z, Chen H, et al.,: Traditional Chinese herbal products for stable angina. Cochrane Database Syst Rev 2010;2010(5):CD004468.

Qureshi A, Naughton DP, Petroczi A: A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. J Diet Suppl 2014;11(1):64‐79.

GamalEl Din SF: Role of Tribulus terrestris in Male Infertility: Is It Real or Fiction?. J Diet Suppl 2018;15(6):1010‐1013.

Belemnaba L, Ouédraogo S, Nitiéma M, et al., : An aqueous extract of the Anogeissus leiocarpus bark (AEAL) induces the endothelium-dependent relaxation of porcine coronary artery rings involving predominantly nitric oxide. J Basic Clin Physiol Pharmacol 2018;29(6):599‐608.