- 期刊
Necrotizing Periodontal Disease Following Chemotherapy for Refractory Diffuse Large B-Cell Lymphoma: A Case Report and Review of Literature
摘要
Despite the latest developments in chemotherapeutic regimens and protocols to reduce chemotherapy-related adverse side-effects, some appear unavoidable and could be severe enough to impair the patient's quality of life. The most common oral side effects of chemotherapy are oral mucositis, jaw osteonecrosis, oral infections caused by bacteria, fungi, and viruses, dental anomalies, hyposialia, xerostomia, and taste changes. These side effects have negative impacts on the patient's oral intake and nutrient status. We report a 43-year-old man with refractory B-cell non-Hodgkin lymphoma (NHL) who began chemotherapy in September 2005 at E-Da Hospital. After his fifth cycle of chemotherapy, multiple necrotic gingival lesions appeared accompanied by severe pain. The patient was referred to the dental department and diagnosed with necrotic periodontitis, which is a rare and atypical necrotizing periodontal disease with a sudden onset and rapid progression within a few days. The disease is characterized by dislodgement of necrotic tissue from the marginal gingiva together with rapid bone destruction. This report aims at highlighting the importance of interdisciplinary cooperation through which physicians familiar with necrotizing periodontitis disease (NPD) could help in making timely diagnosis that allows prompt treatment.