With the popularization of higher education today, the competition for academic qualifications is becoming more and more intense in the competition for jobs, which will undoubtedly cause the problem of over-qualification. Over-qualification puts forward new requirements for enterprise managers and human resource management. Whether employees will feel alienated from work due to over-qualification, which will further affect employees' resignation intention, and whether workplace friendship can be used as a moderating variable between over-qualification and resignation intention. It is the focus of this study to prove through empirical analysis.