In the past, scholars' research on expatriates mainly focused on their cross-cultural adaptation, but the research on the sense of cultural alienation is still relatively lacking. This paper mainly adopts the quantitative research method, based on the review and analysis of previous literature, and takes the trait activation theory and self-regulation theory as the starting point to establish the research model. The purpose of this study is to explore the mechanism of cultural alienation on expatriates' cross-cultural adaptation and work engagement, and the moderating effect of resilience on cultural alienation and expatriates' cross-cultural adaptation. The development of cultural alienation has a negative impact on other employees' work engagement behavior; cultural alienation has a negative impact on other employees' cross-cultural adaptability; employees' cross-cultural adaptation has a positive impact on employees' work engagement behavior; psychological resilience inhibits the impact of cultural alienation and cross-cultural adaptation.