Positive orientation is a relatively new construct that plays an important role in people's adjustment and functioning, which leads to a potential impact on psychological distress. Conceptually the first aim of this research is to investigate whether self-esteem, life satisfaction, and optimism are constructed under positive orientation amongst clinical and non-clinical samples in Malaysia. Secondly, it will investigate the role of positive orientation constructs in predicting psychological distress. This research will investigate the reliability of the instruments and individual level of positive orientation and psychological distress amongst university students. Cross-sectional survey was employed, purposive sampling was used, with a total of 40 samples participating in the study. Rosenberg's Self-Esteem Scale, Satisfaction with Life Scale, Life Orientation Test-Revised, and Depression, Anxiety, and Stress Scale-21 Items were used. The reliability analysis result ensured that all instruments are reliable for more in-depth analysis of the variables later. The descriptive analysis in this research note provides meaningful explanations on the demographic characteristics, participants' level of positive orientation construct and psychological distress. These findings will contribute to determining the constructs under positive orientation and positive orientation's predictive role on psychological distress among samples in Malaysia.