The current response by main countries to the crisis of Covid-9 is to double down whatever methods adopted during the financial tsunami occurred between 2007 and 2009. Nonetheless, the overshooting of financial markets worldwide as well as a rapid increase of corporate cash reserves may indicate the opposite. Recently the sharp rise in yields and increasing inflation expectations forced the Federal Reserve (FED) to change tone over monetary stimulus. Compared to last crisis, the contrast then and now shows the lack of physical investment and collective fiscal expansion willingly, both at the country level and by key companies. That businesses may interact under "co-opetition", taking simultaneously competitive and cooperative activities, was recognized formally near the end of the 20th century. A further complication to most multinational firms is the chance for US-CHINA decoupling throughout the crisis of COVID-19. It would be striking to hear of a similar position proposed by President Biden. The president made his first diplomacy speech on February 4th, 2021 and said that "But we're also ready to work with Beijing when it's in America's interest to do so. We'll compete from a position of strength by building back better at home and working with our allies and partners." The emphasis of resilient production and concern of national security has led to a push to restructure the global supply chain. Newly announced executive order by the White House is to conduct a 100-day review of four key industries and a yearlong review for six product sectors, covering defense, public health, information technology, transportation, energy and food production. Thereby, it would be interesting to tackle the following issues by multinationals on every front: 1. How will design of supply chains and direct investment be affected out of the US-China Decoupling, both vertically and horizontally? 2. How will decoupling impact China's technology advancements and her long-term economic policy, say the so called "dual circulation strategy"? 3. Can we look for a silver lining out of the great rivalry?