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成人補充維生素E對於慢性病之預防或延緩及治療效果：實證營養研究綜論（一）
The effects of vitamin E supplementation on the prevention, delay and treatment of chronic diseases in adults: an evidence-based of nutrition review (1)
摘要
維生素E是體內重要的抗氧化營養素，也是大眾廣泛作為預防或改善慢性疾病營養補充劑。本文收集五年內的統合分析綜論加以歸納維生素E與心血管疾病的關係，至今仍無充分的證據可支持維生素E補充在預防心血管疾病發生率與死亡率方面有顯著預防效益。在預防阿茲海默症風險方面共有5篇綜論，目前的資料顯示健康人或是輕度認知障礙藉由維生素E補充並無助益，但是相關的隨機分派實驗總研究篇數仍然不多，因此還需要更多研究加以驗證。在改善第二型糖尿病方面共有9篇綜論，患者補充維生素E不會降低空腹血糖，但可以降低HbA1c，然而因相關收集的文獻大多有高偏差風險，存在著研究證據等級較低的問題，致使上述結論仍有其不確定性。基於以上分析，維生素E作為營養補充劑在預防或治療心血管疾病、阿茲海默症及第二型糖尿病的效果仍不確定，需要更進一步的研究來驗證其功效與安全性。
並列摘要
Vitamin E is an essential antioxidant nutrient in the body, widely supplemented by people to prevent or improve chronic diseases. All the meta-analysis reviews over the past five years are summarized and organized in this article. First, there are a total of reviews addressing the prevention of the incidence of cardiovascular diseases and mortality. However, to date, there is insufficient evidence to support significant preventive benefits of vitamin E. In the context of preventing the risk of Alzheimer's disease, there are 5 reviews available. Current data suggest that supplementation with vitamin E does not provide benefits for healthy adults or those with mild cognitive impairment. However, the total number of relevant randomized controlled trials is still limited, and further research for validation is necessary. Regarding the improvement of type 2 diabetes, there are 9 reviews included. Patients supplemented with vitamin E showed no reduction in fasting blood sugar, but a decrease in HbA1c was observed. Nevertheless, due to the predominance of lower-quality evidence in the existing literature, more research is required to confirm these findings. Based on the above analysis, the effectiveness of vitamin E as a nutritional supplement in preventing or treating cardiovascular diseases, Alzheimer's disease, and type 2 diabetes remains uncertain, further research to verify its efficacy and safety is required.