The Rheinmetall Rh-120 is a smoothbore tank gun developed by Rheinmetall and is recognized as the global standard. This study focuses on analyzing the autofrettage stress in the Rheinmetall Rh-120 and investigates the impact of the autofrettage stress on the barrel firing stress in response to the future national defense weapons domestic production policy. For the estimation and analysis, the Le Duc method and Rheinmetall's autofrettage stress algorithm were used. Finally, this study revealed the result of the autofrettage stress and the effect of the percentage of the autofrettage stress to firing stress. The results led to the following conclusions: (1) The autofrettage stress counteracts the creep stress, ensuring that the gun barrels remain within a safe range. (2) The appropriate percentage range for the thickness of the autofrettage is between 60 and 70%.