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P16和Ki-67在宮頸鱗狀上皮內病變的診斷價值
The Value of P16, Ki-67 in the diagnosis of cervical squamous intraepithelial lesion
摘要
目的：探討P16、Ki-67在宮頸鱗狀上皮內病變分級診斷中的意義。方法：收集本院陰道鏡檢查及宮頸活檢病例66例，進行P16、Ki-67免疫組織化學檢測。結果：P16在慢性宮頸炎、低級別鱗狀上皮內病變（LSIL）及高級別鱗狀上皮內病變（HSIL）中的陽性表達率分別為0.00%、6.90%及100%。Ki-67在慢性宮頸炎、LSIL及HSIL中的陽性表達率分別為0.00%、3.45%及95.45%。HSIL與LSIL及慢性宮頸炎比較，P16、Ki-67的表達率明顯增高，差異均有統計學意義（P <0.05）。結論：聯合P16、Ki-67免疫組織化學檢測，在宮頸鱗狀上皮內病變的分級診斷及治療中具有重要意義，P16在宮頸鱗狀上皮內病變中的表達更具特異性。
並列摘要
Objective: To study the significance of P16, Ki-67 testing in grading diagnosis of cervical squamous intraepithelial lesion. Methods: 66 cases of cervical biopsy specimens from colposcope were collected. The expressions of P16, Ki-67 were evaluated by immunohistochemical staining. Results: The positive rates of P16 in chronic cervicitis, low-grade squamous intraepithelial lesion(LSIL) and high-grade squamous intraepithelial lesion(HSIL) were 0.00%, 6.90% and 100%. The positive rates of Ki-67 in chronic cervicitis, LSIL and HSIL were 0.00%, 3.45% and 95.45%. The positive rates of P16 and Ki-67 in HSIL were higher than in chronic cervicitis and LSIL (P<0.05). Conclusion: P16 and Ki-67 testing play an important significance in grading diagnosis and treatment of cervical squamous intraepithelial lesions. The specificity of P16 is higher in the diagnosis of the cervical squamous intraepithelial lesion.