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242例癲癇患者藥物療效分析
Analysis of drug efficacy in 242cases of epilepsy
摘要
目的：分析本院242例癲癇患者抗癲癇藥物的療效。方法：回顧性收集在本院於2011年9月～2013年8月門診或住院的242癲癇病人的臨床資料，通過計算治療前後發作次數的變化，用自身對照的方法，應用SPSS軟件分析，評定抗癲癇藥物的療效。結果：（1）76%（185例）癲癇發作為單種類型發作；（2）用藥種類比較集中，主要是丙戊酸鈉，共107例、苯妥英鈉38例、卡馬西平20例。使用新藥例數較少；（3）單藥丙戊酸鈉治療效果好，比較國外文獻報導療效更優；（4）不良反應發生率低，但卡馬西平的皮疹發生率相對較高。結論：本組資料顯示，丙戊酸鈉、卡馬西平是最常用有效的抗癲癇藥物。療效比較好的原因可能與病例來源偏差相關。
並列摘要
Objective: To analyze the effectiveness of antiepileptic drugs in patients with epilepsy. Methods: A retrospective survey was conducted of 242 epilepsy patients at OPD and inpatients wards from September 2011 to August 2013. Clinical data, and seizure times before and after treatment were recorded and used for evaluating the medication effects by SPSS. Results: (1) 76% (185cases) epilepsies are single type. (2) Antiepileptic drugs were mostly Sodium Valproate (107 cases), Phenytoin (38cases) and Carbamazepine (20cases). Fewer new drugs were used in the treatment. (3) Better efficacy of Sodium Vaproate was found, compared to research conducted in foreign countries. (4) Side effect rates were low, but the rash rates were relatively high in Carbamazepine. Conclusion: From the data showed Sodium Valproate and Carbamazepine are the most common and effective antiepileptic drugs, which may be caused by deviation from the case resource.