Objective: To study the efficacy of tensional mesh skin graft combined with vacuum assisted closure technique for treatment of skin defect Methods: 7 cases of skin defect of limb treated with tensional mesh skin graft combined with vacuum-assisted closure technique. Results: Survival rate of skin graft was 98%-100% at 2 weeks. Resurfacing wound within meshes in 20-35 days. Mobilization of joint were recovery without straight scar. Conclusion: Tensional mesh skin graft combined with vacuum assisted closure technique improved the utilization rate and survival rate of skin graft.