Objective: To evaluate the bleeding of raw surface,wound recovery and lesion replase of epiglottic cystectomy with semiconductor laser under self-retaining laryngoscope. Methods: Retrospective study was applied between different surgical methods in the bleeding of raw surface, wound recovery and lesion replase of epiglottic cystectomy. It contained 73 cases with final diagnosis of epiglottic cyst which accepted cystectomy with semiconductor laser under self- retaining laryngoscope by general anesthesia during 2010 until Oct 2012. Results: It was minor bleeding, it was better than cystectomy under direct laryngoscope or laryngeal mirror by topical anesthesia. Conclusion: Epiglottic cystectomy with semiconductor laser under self-retaining laryngoscope by general anesthesia is a well-complianted, less painful,thoroughly-resected,minimally recurred and extremely securited surgical approach.