As the intersection of computer technology and humanities, the rise of digital humanities has injected new vitality into humanities research and industry practice. From the perspective of digital humanities, this paper takes some professional databases developed at home and abroad as case to deeply explore the database construction concept, function design, operation mode and application scenarios under the influence of digital humanity. On the basis of case analysis, this paper tries to provide reference for the feasibility path to professional database fusion publishing practice of publishing institutions, and proposes that we should change the role cognition in the concept dimension, dig deep into their own characteristics, and realize the integration of superior resources. In the method dimension, humanities research should be taken as the cognitive framework and cutting-edge digital technology as the key means to extend the database value chain. In the system dimension, we should pay attention to personnel training, institutional coordination and multi-party financing. In the scene dimension, it should meet the personalized needs of users in the mobile era and open up multiple application scenarios.