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百歲老人新冠OMICRON感染者臨床特點研究
The clinical characteristics of centenarians infected with COVID-19 OMICRON
摘要
目的：研究百歲老人感染新冠OMICRON的臨床特點。方法：回顧性分析2022年12月至2023年3月，OMICRON流行期間，澳門某醫院住院確診的百歲老人新冠感染者的臨床特點，觀察接種疫苗佔比、死亡佔比，分析死亡組與好轉組的臨床差異。結果：25例百歲老人，診斷危重型8例、重型7例，中型9例，輕型1例，危重症佔比32%（95%CI：15%～54%）。死亡4例，佔比16%（95%CI：5%～36%）；好轉出院21例，佔比84%（95%CI：64%～95%）。出現症狀以發熱最多、其次為呼吸道症狀；均合並基礎疾病，以高血壓、心腦血管疾病最多。14例接種疫苗，均為國藥滅活疫苗，接種疫苗佔比56%（95%CI：35%～76%）；在發病前2週至12週之間接種最後1針疫苗者6例、無死亡病例，超出以上區間組8例、死亡3例，死亡佔比兩組分別為0%（95%CI:0%～46%）和38%（95%CI:9%～76%）。結論：百歲老人感染新冠OMICRON者，均合併基礎疾病。臨床表現仍以發熱、呼吸道症狀多見。發病前2週至12週之間接種最後1針疫苗者死亡佔比有下降趨勢。
並列摘要
Objective To study the clinical characteristics of centenarians infected with COVID-19 OMICRON. Methods: Centenarians diagnosed with COVID-19 infection who were hospitalized during the OMICRON epidemic in Macao from December 2022 to March 2023, were retrospectively analyzed. We observed the clinical characteristics, the vaccination proportion, death proportion and analyzed the death group and improvement group clinical differences. Results: 25 centenarians were adopted, 8 cases were diagnosed as critical, 7 cases were severe, 9 cases were medium, and 1 case was mild, critical were accounting for 32% (95% CI: 15%~54%). 4 cases died, accounting for 16% (95%CI: 5%~36%); 21 cases improved and discharged, accounting for 84% (95%CI: 64%~95%). The most common symptoms are fever, followed by respiratory symptoms; all are combined with underlying diseases, and hypertension, cardiovascular and cerebrovascular diseases were the most common diseases. 14 cases were vaccinated, all of which were inactivated vaccines (Sinopharm vaccine), accounting for 56% (95%CI: 35%~76%); 6 cases were vaccinated with the last dose of vaccine between 2 weeks and 12 weeks before the onset of OMICRON, and there were no deaths. 8 cases who were vaccinated with the last dose of vaccine less 2 weeks or over 12 weeks, and there were 3 deaths. The death proportions in the two groups were 0% (95%CI: 0%~46%) and 38% (95%CI: 9%~76%) respectively. Conclusion: Centenarians infected with COVID-19 OMICRON all have underlying diseases. There are more critical cases, the fatality rate is not higher than that of people under 100 years old, and the clinical manifestations are still mostly fever and respiratory symptoms. The proportion of deaths among those who received the last dose of vaccine between 2 weeks and 12 weeks before the onset of OMICRON showed a downward trend.