In this study, convenience sampling selected Chinese students from University A, the largest number of Chinese students in Thailand, as the subjects of the distribution of electronic questionnaires. A total of 521 valid samples were obtained using the study instruments including the Self-Acceptance Scale, Mental Health scales, and Academic Self-efficacy scales. The results are as follows: the self-acceptance, mental health and academic self-efficacy in gender, grade, self-acceptance has a significant positive effects of self-acceptance on mental health; academic self-efficacy plays a mediating role between self-acceptance and mental health.