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【論文摘要】熱滅活植物乳桿菌TWK10對運動表現及身體組成之影響
【論文摘要】The effects of heat-killed Lactiplantibacillus plantarum TWK10 on exercise performance and body composition
摘要
目的：愈來愈多的研究證實攝取益生菌能有效改善精英運動員和普通人群的健康狀況及運動表現。植物乳桿菌TWK10可視為一種益生菌菌株，臨床實證顯示TWK10能顯著提升運動表現、減少疲勞、優化身體組成以及改善衰老相關的退化。本研究針對TWK10活菌、熱滅活TWK10在調節運動表現和身體組成等方面進行了比較分析。方法：53名未受過專業運動訓練的健康成年人依據其個人的運動能力均分為三組，包括對照組、TWK10組（TWK10活菌，3×10^(11)cfu／天）和TWK10-hk組（熱滅活TWK10，3×10^(11)細胞／天）。運動耐力表現是在85%VO_(2max)的運動強度下以跑步機執行；而疲勞的相關評估則是在60%VO_(2max)固定強度的運動挑戰下執行，並在特定的時間點採集血液樣本，包括基線（0）、開始運動5分鐘（E5）、10分鐘（E10）、15分鐘（E15）和30分鐘（E30），以及運動挑戰後的20分鐘（R20）、40分鐘（R40）、60分鐘（R60）和90分鐘（R90）。身體組成是由生物電阻抗分析儀（InBody770）進行檢測。結果與結論：在六週的介入後，與對照組相比，TWK10活菌、熱滅活TWK10皆可有效提升運動表現以及減少疲勞症狀，並能降低運動引起的發炎反應。此外，TWK10活菌可透過增加肌肉質量和減少脂肪量來優化身體組成，其效果與熱滅活TWK10相比更為顯著。
並列摘要
Introduction: Emerging evidence supports the role of probiotics supplementation in improving the health status and exercise performance of elite athletes and the general population. Lactiplantibacillus plantarum TWK10, a probiotic strain, has been demonstrated to exert beneficial effects on exercise performance, reducing fatigue, improving body composition, and ameliorating aging-related declines in humans. In this study, a comparative analysis of viable and heat-killed TWK10 in the regulation of exercise performance and body composition was performed. Methods: Fifty-three healthy adults without professional athletic training were recruited and equally assigned to three groups, including control, TWK10 (viable TWK10, 3×10^(11) cfu/day), and TWK10-hk (heat-killed TWK10, 3×10^(11) cell/day) groups based on individual exercise capacity. Endurance performance was assessed on the treadmill at 85% VO_(2max) workload. For the assessment of fatigue-related indices, blood samples were collected at indicated time points, including baseline (0), 5 min (E5), 10 min (E10), 15 min (E15), and 30 min (E30) during the 60% VO_(2max) fixed intensity exercise challenge, and at 20 min (R20), 40 min (R40), 60 min (R60), and 90 min (R90) after exercise challenge. Body composition was measured by a bioelectrical impedance analyzer (InBody 770, Seoul, Korea). Results and Conclusions: After six weeks of administration, subjects receiving either viable or heat-killed TWK10 showed significantly improved exercise performance and fatigue-related features, and reduced exercise-induced inflammatory responses as compared to the controls. Furthermore, viable TWK10 significantly contributed to the improvements of body composition by increasing muscle mass and reducing fat mass, and the efficacy was greater than that observed with heat-killed TWK10.