In this paper Enriched Basil Seed Optimization (EBS), Little Child Imagination and Learning Inspired (LISPO), Malignant Neoplasm of Uterine Algorithm (MNUO) designed. Key objectives of the paper are Actual Power Loss Reduction and Voltage stability Enhancement in Electrical Power System. Basil seed algorithm based on the connotation amongst Basil and seeds. In pursuit of the optimal standards of dispersal of Basil seeds are significant and it is not conceivable to produce the seeds in capricious manner. In order to augment the process, actions of the Valonia ventricosa been integrated into the procedure. LISPO procedure utilizes the Golden proportion and imitates the intellectual knowledge and kid's sketch phases by means of finger compression girth, span and golden proportion of the kid's sketch. By experimental and slip, the kids’ sketches progress from scrawl to an attractive sketch. Malignant Neoplasm of Uterine mathematically designed to formulate the MNUO algorithm. Preliminary Malignant Neoplasm magnitude in the uterus computed mathematically and it emphasizes the location in the procedure. Proposed EBS, LISPO and MNUO validated in 23 Benchmarking functions, IEEE 30 and 354 bus systems.